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  14. Third, given that aberrant activation of the PI3K pathway has been implicated in resistance to HER2 targeted therapy 64, one might hypothesize that GATA3 mutations may be a mechanism of resistance to HER2 targeted therapy and that MDM2 inhibitors may act synergistically with trastuzumab in ER HER2, GATA3 mutant breast cancers buy zithromax 1 gram

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